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Round Up Email April 2024

In this month's Round Up highlighted areas include paracetamol use in pregnancy, an update of the listeriosis section and an explanation of the mechanism of action of dual GLP-1/GIP receptor agonists.

Question 1
Prostate cancer and exercise – Does the evidence show that exercise reduces incidence of prostate cancer or may slow progression of prostate cancer or both?: Prostate cancer and exercise
With respect to prostate cancer and exercise, which statement is false?
- Evidence suggests that men who increased their cardiorespiratory fitness (CRF) by more than 3% had a significantly lower risk of prostate cancer incidence.
- Cycling is a possible cause of increased PSA.
- Evidence suggests that exercise has no beneficial in established prostate cancer.
Question 2
Paracetamol use in pregnancy and breastfeeding – What is the relationship between use of paracetamol during pregnancy and incidence of wheezing in offspring? What about the relationship between autism and use of paracetamol during pregnancy? Does paracetamol use the analgesia of choice during breastfeeding?: Paracetamol use in pregnancy
With respect to the use of paracetamol in pregnancy and breastfeeding, which statement is false?
- Paracetamol is the painkiller of choice whilst breastfeeding.
- Frequent use of paracetamol in late pregnancy may increase the risk of wheezing in the offspring.
- A recent Swedish study confirmed the association between paracetamol use in pregnancy and risk of autism in children of mothers who had used paracetamol during pregnancy
Question 3
Listeriosis – Listeriosis is a rare infection caused by Listeria monocytogenes, an aerobic gram-positive rod found in some semi-processed foods including soft cheeses and pate; but can pregnant women acquire listeriosis from sheep at lambing time?: Listeriosis
With respect to listeriosis, which statement is false?
- Listeria monocytogenes, an anaerobic gram positive rod found in some semi-processed foods including soft cheeses and pate.
- Listeriosis is a rare but severe systemic infection that includes bacteraemia, meningitis, and encephalitis and in pregnant women can lead to miscarriage and stillbirth.
- Direct contact with infected animals can occasionally cause infection.
Question 4
Bacterial meningitis – this section of GPnotebook has been updated.: Bacterial meningitis
With respect to bacterial meningitis, which statement is false?
- Haemophilus influenzae type b is a common cause of meningitis in the UK.
- In babies under 3 months old, group B Streptococcus, Escherichia coli and other coliforms are common causes of meningitis.
- A previous episode of bacterial meningitis or meningococcal disease is a risk factor for development of bacterial meningitis.
Question 5
Tirzepatide – this section of GPnotebook has been updated.: Tirzepatide - a dual GIP and GLP-1 (GLP1) receptor agonist
With respect to tirzepatide, which statement is false?
- Tirzepatide is a dual glucose-dependent insulinotropic polypeptide-GLP-1 receptor agonist.
- The most common side effect associated with tirzepatide is headache.
- In the SURPASS-2 trial, tirzepatide was noninferior and superior to semaglutide with respect to the mean change in the glycated hemoglobin level from baseline to 40 weeks.
Question 6
Evidence relating to the use of Use of SMS text messaging and videos in bowel cancer screening has been summarised on GPnotebook.: Use of SMS text messaging and videos in bowel cancer screening
With respect to use of SMS text messaging and videos in bowel cancer screening, which statement is true?
- In the the SMARTscreen cluster randomised trial, use of SMS text messaging and videos increased uptake of screening by about 5%
- In the the SMARTscreen cluster randomised trial, use of SMS text messaging and videos increased uptake of screening by about 10%
- In the the SMARTscreen cluster randomised trial, use of SMS text messaging and videos increased uptake of screening by about 15%

Round Up Email April 2024

Question 1

Question 2

Question 3

Question 4

Question 5

Question 6