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Round Up Email December 2022

This month's Round Up highlights changes in evidence relating to dementia - from the ground-breaking trial involving Lecanemab to evidence relating to use of aspirin and exercise and effects on risk of subsequent dementia.

  • Question 1

    Increased homocysteine levels and risk of dementia - increased plasma homocysteine level is a strong, independent risk factor for the development of dementia and Alzheimer's disease. Even in the absence of vitamin deficiency, homocysteine levels can be reduced by administration of high-dose supplements of folic acid and vitamins B(6) and B(12). Does trial evidence support the use of high-dose vitamin B supplementation reducing dementia risk?: Increased homocysteine levels and risk of Alzheimer's disease and dementia

    1) With respect to increased homocysteine levels and risk of dementia, which statement is false?

  • Question 2

    Lecanemab in Alzheimer's disease – the facts about this new therapy are summarised on GPnotebook.: Lecanemab in Early Alzheimer's Disease

    2) With respect to Lecanemab in Alzheimer's disease, which statement is false?

  • Question 3

    Benefits of exercise in reducing risk of dementia – Exercise reduces risk of development of dementia by about 50%. How many steps per day are required to reduce dementia risk? Is there an optimum number?: Exercise and dementia risk

    3) With respect to exercise and reduction of dementia risk, which statement is false?

  • Question 4

    Type 2 diabetes and dementia risk – the onset of dementia in people with type 2 diabetes is earlier than in comparable populations without diabetes – is the onset 18 months earlier, two and half years earlier, or three and half years earlier?: Diabetes (DM) and dementia risk

    4) With respect to type 2 diabetes and dementia risk, which statement is false

  • Question 5

    Association of air pollution and risk of dementia – this subject is summarised on GPnotebook.: Cognitive decline , dementia and air pollution

    5) With respect to the association of air pollution and risk of dementia, which statement is false

  • Question 6

    Aspirin use and dementia prevention - daily low-dose aspirin has been shown to cause an 11% proportional decrease in the risk of major vascular events (including a 19% reduction in ischaemic strokes) but a 43% proportional increase in the risk of serious bleeding. However, the use of aspirin has not been shown to reduce dementia risk. For more information then see GPnotebook.: Aspirin and dementia

    6) With respect to aspirin use in type 2 diabetes and dementia risk, which statement is false

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