the principal mechanism in which angiotensin II receptor inhibitors lower blood pressure is probably inhibition of angiotensin-mediated vasoconstriction
the antihypertensive efficacy of angiotensin II receptor inhibitors appears to be equal to that of atenolol or ACE inhibitors
angiotensin II receptor inhibitors and thiazide diuretics may be combined, resulting in additive hypotensive effects; an additive effect also occurs if angiotensin II receptor inhibitors are used with beta blockers
the combination of an ACE inhibitor and an angiotensin II receptor antagonist is not recommended (1)
angiotensin II receptor inhibitors have a gradual onset of action and adverse effects such as first dose hypotension are rare
the ACD strategy for hypertension management suggests an ACE inhibitor (or angiotensin II inhibitor) as first-line therapy for younger (non-black) patients
the VALUE trial compared the use of valsartan to amlodipine in the management of hypertension (see linked item)
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