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Drug-induced bradycardia

Authoring team

Causes: (1,2)

  • drugs that depress sinus node function eg digoxin, beta blocking agents, methyldopa
  • some anti-arrhythmic drugs may cause difficulties in patients predisposed to sinus node dysfunction eg disopyramide, amiodarone, verapamil, flecainide
  • uncommon causes of bradycardia or sinus arrest include lithium, cimetidine, co-dergocrine mesilate

Reference:

  1. Tisdale JE, Chung MK, Campbell KB, et al. Drug-Induced Arrhythmias: A Scientific Statement From the American Heart Association. Circulation. 2020 Oct 13;142(15):e214-e233.
  2. Griffiths C, Ioannou A, Dickinson B, et al. Drug-related bradycardia precipitating hospital admission in older adults: an ongoing problem. Eur J Hosp Pharm. 2021 Feb 24.

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