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Prognosis

Authoring team

There is variable fertility in individuals affected by this condition. The long term prognosis is mainly determined by the cardiac problems. This may occur in up to 75% of cases and is the most common cause of death for people with the syndrome (1)

Hypertrophic cardiomyopathy may resolve, or may become rapidly progressive with a fatal outcome. There is some suggestion of late-onset arrhythmias and congestive cardiac failure (2)

Reference

  1. Jorge AA, Malaquias AC, Arnhold IJ, et al. Noonan syndrome and related disorders: a review of clinical features and mutations in genes of the RAS/MAPK pathway. Horm Res. 2009;71(4):185-93.
  2. Colquitt JL, Noonan JA. Cardiac findings in Noonan syndrome on long-term follow-up. Congenit Heart Dis. 2014 Mar-Apr;9(2):144-50.

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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