Physiology of mannose binding protein
Mannose binding protein (MBP) is:
- a serum collagenous lectin (collectin)
- an acute phase protein, synthesised in the liver in response to infection
- part of the body's first line of defence
MBP can opsonise pathogens directly, resulting in accelerated phagocytosis.
MBP can activate the classical and alternative complement pathways by:
- taking the place of C1q by binging C1r and C1s
- binding a novel factor (MBP-associated serine protease) which can activate the classical complement pathway
Related pages
Create an account to add page annotations
Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.