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Follicle-stimulating hormone

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Follicle-stimulating hormone is a gonadotrophin released by the anterior pituitary in response to pulsatile gonadotrophin-releasing hormone stimulation.

It is responsible in females for the early growth of ovarian follicles

In males, together with testosterone, it stimulates Sertoli cells to release the hormone inhibin and induces sperm production. Inhibin and testosterone reduce gonadotrophin-releasing hormone (and hence gonadotrophin) secretion via negative feedback. (2)

Reference:

  1. Barbieri RL. The endocrinology of the menstrual cycle. Methods Mol Biol. 2014;1154:145-69.
  2. Boepple PA et al. Relative roles of inhibin B and sex steroids in the negative feedback regulation of follicle-stimulating hormone in men across the full spectrum of seminiferous epithelium function. J Clin Endocrinol Metab. 2008 May;93(5):1809-14

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