This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages before signing in

C ANCA

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Two ANCA patterns were originally identified by indirect immunofluorescence (IIF)

  • 'classical' C-ANCA is associated with antibodies reacting with the 29–30 kDa elastinolitic enzyme, serine proteinase 3 (PR3)
    • composed of 229 amino acids and found in the azurophilic granules of neutrophils and monocytes
    • studies have shown that when the IIF and ELISA results are combined, the presence of C-ANCA and anti-PR3 has 99% specificity for the diagnosis of primary systemic vasculitis
      • classical C-ANCA pattern on IIF and/or anti-PR3 are predominantly found in patients with Wegerner's granulomatosis
        • C-ANCA is a sensitive and specific test for WG - 90% of patients with Wegener's granulomatosis are C-ANCA positive.

Related pages

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.