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Lymphoma (stomach, non-Hodgkin's)

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Non-Hodgkin's lymphoma is the commonest non-epithelial malignant neoplasm of the stomach, accounting for about 3% of all gastric neoplasms. Helicobacter pylori is associated with the development of gastric lymphoma.

Presentation is usually late. Symptoms are often non-specific for example anorexia and weight loss.

Contrast radiography may show anything from a large tumour mass to accentuated rugae.

Treatment is dependent upon staging:

  • if the tumour is confined to the stomach:
    • radical resection is indicated
    • this may be followed by radio- and chemotherapy
  • lymph node involvement:
    • radiotherapy and chemotherapy are indicated
  • low-grade primary gastric lymphomas may completely regress after eradication of H. pylori infection

The prognosis is better for gastric lymphoma - 40-50% five year survival compared to those sited more distally in the gastrointestinal tract.

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