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Proton pump inhibitors in the treatment of dyspepsia

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PPI doses relating to management of dyspepsia, oesophagitis and peptic ulcer disease

* lower than the licensed starting dose for esomeprazole in GORD, which is 40 mg, but considered to be dose-equivalent to other PPIs. When undertaking meta-analysis of dose related effects, NICE classed esomeprazole 20 mg as a full-dose equivalent to omeprazole 20 mg

***40 mg is recommended as a double dose of esomeprazole because the 20-mg dose is considered equivalent to omeprazole 20 mg.

*dose, specifically for severe oesophagitis

PPI doses for H pylori eradication therapy

NICE. Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management . Clinical guideline CG184. Published September 2014, last updated October 2019. 

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PPI	Full/Standard dose	Low dose (on demand dose)	Double dose
Esomeprazole	20 mg* once a day	Not available	40 mg*** once a day
Lansoprazole	30mg once a day	15mg per day	30 mg** twice a day
Omeprazole	20 mg once a day	10mg* per day	40 mg once a day
Pantoprazole	40 mg once a day	20mg per day	40mg twice a day
Rabeprazole	20mg once a day	10mg per day	20mg twice a day

PPI	Full/Standard dose	Low dose (on demand dose)	Double dose/High dose
Esomeprazole	40 mg* once a day	20mg* once a day	40 mg* twice a day
Lansoprazole	30mg once a day	15mg per day	30 mg** twice a day
Omeprazole	40 mg* once a day	20mg* per day	40 mg* twice a day
Pantoprazole	40 mg once a day	20mg per day	40mg** twice a day
Rabeprazole	20mg once a day	10mg per day	20mg** twice a day

PPI	Dose (twice daily)
Esomeprazole	20mg
Lansoprazole	30mg
Omeprazole	20-40mg
Pantoprazole	40mg
Rabeprazole	20mg

Proton pump inhibitors in the treatment of dyspepsia

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