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Rotor's syndrome

Authoring team

Rotor's syndrome is an autosomal recessive condition characterised by a chronic, predominantly conjugated hyperbilirubinaemia. The mechanism is similar to that seen in the Dubin-Johnson syndrome, with defective excretion of organic anions into bile.

The liver is a normal colour on biopsy, unlike Dubin-Johnson syndrome.

The prognosis is excellent.

Reference

  1. Strassburg CP. Hyperbilirubinemia syndromes (Gilbert-Meulengracht, Crigler-Najjar, Dubin-Johnson, and Rotor syndrome). Best Pract Res Clin Gastroenterol. 2010 Oct;24(5):555-71

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