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Prochlorperazine

Authoring team

This is a phenothiazine drug which is an effective:

  • anti-emetic
  • labyrinthine sedative
  • anti-psychotic

Note - as a first-generation antipsychotic, prochlorperazine can cause a variety of adverse effects. Significant extrapyramidal symptoms, including acute dystonia, tardive dyskinesia, Parkinsonism, akathisia, and neuroleptic malignant syndrome. Anticholinergic side effects include anorexia, blurred vision, constipation, dry mucosa, and urinary retention. Antihistaminic side effects (blockage of H1 receptor) include sedation.

Reference

  1. Chokhawala KP, Stevens L. StatPearls [Internet]. StatPearls Publishing; Treasure Island (FL): Feb 26, 2023. Antipsychotic Medications.

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