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Cytogenetics

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Complete hydatidiform moles typically have a 46 XX karyotype but with both X chromosomes derived from the father. The female pronucleus of the fertilised egg degenerates and the mole develops by duplication of the male pronucleus. A minority are 46 XY. Very rarely, complete hydatiform moles are associated with a foetus.

Incomplete moles usually have a triploid karyotype, 80% of which are 69 XXY. The remainder are 69 XXX or 69 XYY. Occasionally, mosaic patterns are found. Most incomplete moles are associated with a triploid and defective foetus.


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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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