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Diagnosis of premature ovarian insufficiency

Authoring team

Diagnosing premature ovarian insufficiency

  • take into account the woman's clinical history (for example, previous medical or surgical treatment) and family history when diagnosing premature ovarian insufficiency

  • diagnose premature ovarian insufficiency in women aged under 40 years based on:
    • menopausal symptoms, including no or infrequent periods (taking into account whether the woman has a uterus) and
    • elevated FSH levels on 2 blood samples taken 4-6 weeks apart

  • do not diagnose premature ovarian insufficiency on the basis of a single blood test
  • do not routinely use anti-Müllerian hormone testing to diagnose premature ovarian insufficiency (2)

If there is doubt about the diagnosis of premature ovarian insufficiency, refer the woman to a specialist with expertise in menopause or reproductive medicine

Reference:

  1. Menopause: diagnosis and management. NICE Guideline (November 2015 - last updated December 2019)
  2. Dewailly D, Andersen CY, Balen A, et al. The physiology and clinical utility of anti-Mullerian hormone in women. Hum Reprod Update. 2014 May-Jun;20(3):370-85.

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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