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Chronic DIC

Authoring team

The common causes of chronic disseminated intravascular coagulation (DIC) include:

  • adenocarcinoma:
    • a low grade DIC characteristically results in thrombophlebitis migrans and recurrent venous thromboembolism (Trousseau's syndrome)
    • the mechanism of DIC includes tissue damage, secretion of tissue factor or secretion of other procoagulants

  • retained dead foetus syndrome:
    • initially this is a low grade DIC
    • fulminant DIC will inevitably follow if the uterus is not evacuated

  • liver disease:
    • coagulopathy is characteristic of liver disease - DIC may play a part

  • localised lesions:
    • aneurysms
    • haemangiomata (Kasabach-Meritt syndrome)
    • empyema

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