Drug-induced eosinophilia
- drugs that may cause raised eosinophil count include (1,2,3,4):
- antimicrobials
- such as penicillins, cephalosporins, nitrofurantoin, tetracyclines, daptomycin, fluoroquinolones
- such as penicillins, cephalosporins, nitrofurantoin, tetracyclines, daptomycin, fluoroquinolones
- sulphonamides
- such as sulfasalazine, septrin, dapsone
- such as sulfasalazine, septrin, dapsone
- ranitidine
- allopurinol
- angiotensin converting enzyme (ACE) inhibitors
- anticonvulsants
- such as phenytoin, carbamazepine, lamotrigine
- such as phenytoin, carbamazepine, lamotrigine
- antiretrovirals
- nevirapine, abacavir
- nevirapine, abacavir
- non-steroidal anti-inflammatory drugs (NSAIDs)
- methotrexate
- interleukin-2 (IL-2)
- antimicrobials
Factors such as intercurrent steroid treatment and bacterial or viral infection can transiently lower eosinophil counts (4)
Reference:
- Felig P et al (2001) Endocrinology and Metabolism. McGraw-Hill.
- Hart FD (Ed) (2005). French's Index of Differential Diagnosis.
- NHS Camden CCG. Abnormal FBC guidance - for adults (Accessed 30/10/19)
- Thakker C, Booth H L, Lambert J, Morgan S, Checkley A M. Investigating eosinophilia BMJ 2023; 380 :e070295 doi:10.1136/bmj-2022-070295
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