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Differential diagnosis of acute leukaemia

Authoring team

The differential diagnosis of acute leukaemia includes:

  • if lymphadenopathy present:
    • lymphoma
    • Epstein-Barr virus infection

  • if hepatosplenomegaly present:
    • myeloproliferative disorder
    • lymphoproliferative disorder
    • myelodysplasia
    • metabolic and storage disorders
    • autoimmune disorders

  • pancytopenia without peripheral blast cells:
    • aplastic anaemia
    • marrow infiltration by tumour

  • myelodysplasia

Reference:

  1. Lyengar V et al. Leukemia. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan. 2023 Jan 17.

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