This is a diaminocyclohexane platinum compound which forms crosslinks in DNA, so inhibiting DNA replication.
Treatment with Oxaliplatin is associated with a 10% probability of an objective response when given alone or in combination with 5-fluorouracil and leucovirin in patients who have already received 5-fluoruracil (1).
NICE recommend the use of oxaliplatin in combination with 5-fluorouracil and folinic acid as an option for the adjuvant treatment of patients with stage III (Dukes? C) (2)
Possible adverse effects include:
The summary of product characteristics should be consulted before prescribing this drug.
Reference:
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