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Thrombolytic therapy in myocardial infarction

Authoring team

Thrombolysis in acute myocardial infarction is beneficial up to 12 hr post-onset of symptoms. Optimum increases in survival are seen when therapy is started within 70 min of the onset of symptoms.

Rapid diagnosis and initiation of therapy combined with attention to the contra-indications for thrombolysis are important for the successful management of myocardial infarction.

Note: adults with acute ST-segment-elevation myocardial infarction (STEMI) who present within 12 hours of onset of symptoms should have primary percutaneous coronary intervention (PCI), as the preferred coronary reperfusion strategy. This should be performed as soon as possible but within 120 minutes of the time when fibrinolysis could have been given.

Reference

  1. NICE. Acute coronary syndromes in adults. Quality standard QS68. Published September 2014, last updated November 2020

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