C5 deficiency
Classical and alternative complement pathways converge in C5 complement factor, to activate the lytic pathway
- mainly synthesized by hepatocytes, but also by monocytes, lymphocytes and lung, spleen and foetal intestine cells
- C5 gene is located in chromosome 9q34.1
- C5 complement deficiency
- a rare autosomal recessive inherited disease, associated with recurrent infections episodes, particularly meningitis and extragenital gonorrhoea by Neisseria species - these are the most frequent micro-organisms isolated in these patients
- explained because sera from C5 deficiency patients lack bactericidal activity and have severely impaired ability to induce chemotaxis
- a rare autosomal recessive inherited disease, associated with recurrent infections episodes, particularly meningitis and extragenital gonorrhoea by Neisseria species - these are the most frequent micro-organisms isolated in these patients
Reference
- Kareem S et al. Complement: Functions, location and implications. Immunology. 2023 Oct;170(2):180-192
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