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AIDS and malignant disease

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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HIV infection predisposes to the development of certain neoplasms, whose clinical course may differ from those seen in non-infected individuals.

It is associated with three AIDS defining malignancies - Kaposi’s sarcoma, high-grade B-cell non Hodgkin’s lymphoma and invasive cervical cancer and a number of other malignancies.

Kaposi's sarcoma and non-Hodgkin's lymphoma are examples of this, as in AIDS the course of these tumours tends to be more aggressive and these patients should only be managed in a centre with expertise in the management of these diseases (1).

The UK National Guidelines for HIV Testing 2008 has recommended that HIV screening should be done in all patients with lymphoma since both Hodgkin’s and non-Hodgkin’s lymphomas are linked with HIV infection (2).

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