Flucytosine
Flucytosine has attained approval as an adjunct antifungal agent in treating systemic Candida spp. or Cryptococcus spp. infections.
Off-label, flucytosine is utilized in treating paediatric endocarditis caused by Aspergillus spp. (1)
Cautions: (2)
- blood disorders
- renal and hepatic impairment
- liver function tests and a full blood count are required
- pregnancy and breast feeding
Side-effects:
- rashes
- nausea and vomiting
- diarrhoea
- leucopenia
- thrombocytopenia
Routes of administration;
- Oral; Tablets
- IV infusion
References
- McKeny T et al. Antifungal Antibiotics. Treasure Island (FL): StatPearls Publishing. 2025 Jan.
- British National Formulary (BNF); NICE Evidence Services (UK access only)
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