HPV and genital cancer

• HPV-DNA is found in 85-100% of high-grade cervical precancer
  
  
• infection with HPV type 16 or 18 has been associated with a higher rate of progression of cervical squamous intraepithelial lesions and cancer (1)
  
  
• one study in 106 early carcinomas found the following serotypes:
• HPV 16 55%
• HPV 18 17%
• HPV 33 6%
• HPV 35 1%
• unidentified HPV 10%
• No HPV 16% (Favre et al Lancet 1990)
  
  
• The link between HPV and cervical cancer is strong and epidemiologically it may be considered to be causal

Reference:

• (1) Spitzer M (1998). Am J Obstet Gynecol, 179, 544-56.