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Clinical features

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Most infections in humans are asymptomatic. However, when present there are a wide range of symptoms:

  • mild, self-limiting, non-specific infectious mononucleosis syndrome
  • disseminated, fulminating disease that may damage the brain, eyes, muscles, liver, and lungs
  • in association with AIDS there is often a focal neurological defect with raised intracranial pressure secondary to a space-occupying lesion
  • severe manifestations are seen principally in the immunocompromised patients - for example in AIDS - and in fetuses infected transplacentally as a result of maternal infection
  • chorioretinitis may be associated with all forms, but it is usually a late sequel of congenital disease

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