This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Structure

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Glycogen phosphorylase (GP) exists in two forms:

  • GPa is the active form that converts glycogen to glucose-1-phosphate; it is phosphorylated
  • GPb is the less active form; it is not phosphorylated

Conversion between GPa and GPb depends on the state of phosphorylation:

  • GPa phosphatase converts GPa to GPb by removal of phosphate
  • phophorylase kinase (PK) phosphorylates GPb to GPa

Phosphorylase kinase can exist in 2 forms:

  • PKa is an active form that readily phosphorylates GPb; it is itself activated by phosphorylation
  • PKb is the less active form that is dephosphorylated
  • PKb has a subunit that is similar to troponin-C; this makes it more active in the presence of calcium after phosphorylation

Further, the phosphorylation of PKb to PKa is stimulated by the enzyme protein kinase. Protein kinase is itself made more active by the presence of the secondary messenger cyclic AMP.

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.