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Aspirin and secondary stroke prophylaxis in NRAF

Authoring team

Stroke or TIA in patients with non rheumatic atrial fibrilation in whom intracranial haemorrhage has been excluded should be given aspirin:

  • in NRAF aspirin prevents 40 vascular events per 1000 patient years of treatment (1).
  • definitive anti-platelet therapy should be commenced at 2 weeks post symptoms

Anticoagulation should be introduced subsequently:

  • in NRAF anticoagulation prevents 90 vascular events per 1000 patient years of treatment (1).

Reference:

  • (1) European Atrial Fibrillation Trial Study Group. Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke. Lancet, 1993;342: 1255.

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