Intact nephron hypothesis
In patients with chronic renal failure many of the nephrons are non-functional, however those that remain behave normally.
Normal renal homeostatic mechanisms enable:
- sodium and potassium levels to remain normal until the glomerular filtration rate (GFR) drops below 5 ml/min
- phosphate and urate levels to remain normal until the GFR drops below 20 ml/min
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