This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Interspecific somatic cell hybridization

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Somatic cell hybrids are produced by fusing two somatic cells that have been grown in independent cell cultures. Usually the cells are human and murine, fusion being achieved by a virus.

After fusion, the new cell has temporarily a double chromosome complement that is gradually reduced by random expulsion of either murine or human chromosomes. The remaining chromosomes can be identified by morphology and staining.

In culture, the hybrid cell can be tested for the presence of a variety of gene products. The presence, or deficiency, of these products can be associated with the presence, or absence, of a particular chromosome, thus localising function to site.

Similar principles are used in the production of transgenic animals.

Related pages

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.