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Cannabinoids for the control of chemotherapy induced nausea and vomiting

Authoring team

Nabilone (a synthetic cannabinoid) is licensed for nausea and vomiting caused by cytotoxic chemotherapy, unresponsive to conventional antiemetics at a dose of 1-2mg b.d. orally.

NICE state that the evidence is limited, and of low quality using outdated antiemetics but that it could be an option as an add on where patients have nausea and vomiting despite optimised conventional antiemetics.

ASCO recommend this as an option if olanzapine has already been tried for breakthrough nausea and vomiting. (2)

Reference

  1. NICE. Cannabis-based medicinal products. NICE guideline NG144. Published November 2019, last updated March 2021
  2. Hesketh P et al. Antiemetics: ASCO Guideline Update. J Clin Oncol 38, 2782-2797(2020) Volume 38, Number 24

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