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Clinical and biochemical features of different types of MODY

Authoring team

Clinical and biochemical features associated with type 1 diabetes, type 2 diabetes, and the common subtypes of maturity onset diabetes of the young (MODY)


features

type I DM

type 2 Dm

GCK-MODY

HNF1A/4A-MODY

typical age of diagnosis (years)

10-30

>25

present from birth; presents at any age

15-45

diabetic ketoacidosis

common

rare

rare

rare

insulin dependent

yes

no

no

no

parental history of diabetes

<15%

>50% in young onset type 2 diabetes

if tested one parent usually has impaired fasting glycaemia (may not be previously known)

60-90%

obesity

uncommon

common

uncommon

uncommon

insulin resistance

uncommon

common

uncommon

uncommon

presence of β cell antibodies

>90%

negative

rare

rare

C peptide concentrations

undetectable/low

normal/high

normal

normal

optimal first line treatment

insulin

Metformin

none

Sulfonylurea

GCK - glucokinase.
HNF1A/4A - hepatocyte nuclear factor 1α/4α

Reference;

 

 


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