Effect of low dose, extended-release morphine on chronic breathlessness in chronic obstructive pulmonary disease (COPD)
Low-Dose, Extended-release Morphine on Chronic Breathlessness in Chronic Obstructive Pulmonary Disease (COPD)
- randomized clinical trial including 156 people with COPD and chronic breathlessness, treatment with 8 mg/d and 16 mg/d of oral extended-release morphine for 1 week resulted in a mean difference of -0.3 and -0.3, respectively, for change in the intensity of worst breathlessness compared with placebo; neither difference was statistically significant
- scores range from 0 to 10 (a score of 10 being the worst or most intense) on the numerical rating scale that was used
- concludes:
- extended-release morphine compared with placebo did not significantly reduce the intensity of worst breathlessness in people with COPD (1)
- among people with COPD and severe chronic breathlessness, daily low-dose, extended-release morphine did not significantly reduce the intensity of worst breathlessness after 1 week of treatment
Reference:
Related pages
Create an account to add page annotations
Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.