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SOLVD - prevention arm

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

This multicentre, randomised, double-blind, placebo-controlled trial enrolled 4228 patients with reduced left ventricular function (ejection fraction <35%) but without symptomatic heart failure.

The addition of enalapril to the conventional heart failure treatment resulted in a significant 37% decrease in the incidence of heart failure.


  • SOLVD Investigators. (1992). N Engl J Med. 327, 685-691.

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