Aetiology
The aetiology of rheumatoid arthritis is multifactorial. It is thought to be caused by an interaction among genetic susceptibility and environmental triggers.
- 60% of a population's predisposition to RA is genetically determined
- environmental contribution is not clear although various infective agents have been proposed
- hormonal influences may also exist.
Reference:
- Gravallese EM, Firestein GS. Rheumatoid arthritis - common origins, divergent mechanisms. N Engl J Med. 2023 Feb 9;388(6):529-42.
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