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Deficiencies of Factor's II, V and X are inherited as autosomal recessives. They occur rarely with reported incidences between 1 in 500 000 to 1 in 1 000 000, and result from the production of altered inactive forms of the relevant protein.
Laboratory tests show increased prothrombin and partial thromboplastic times - not corrected by administration of vitamin K; other tests are normal.
Diagnosis is by specific factor assay.
Acquired deficiencies of these diseases may result from: