This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Androgen receptor signalling inhibitors in prostate cancer and cardiovascular risk

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Androgen receptor signalling inhibitors receptors in prostate cancer and cardiovascular risk:

  • a systematic review and meta-analysis of 24 randomized clinical trials involving 22 166 patients found that the addition of androgen receptor signalling inhibitors alongside standard androgen deprivation therapy was associated with significantly increased risk of men experiencing cardiovascular events (1)
    • study selection included randomized clinical trials of ARSI agents (abiraterone, apalutamide, darolutamide, enzalutamide) that reported CV events among individuals with M0 and M1, hormone-sensitive prostate cancer (HSPC) and castration-resistant prostate cancer (CRPC)
    • it was found that addition of androgen receptor signalling inhibitors to traditional androgen deprivation therapy was associated with an increased risk of all-grade (RR 1.75; 95% CI 1.50-2.04; P < 0.001) and grade ≥3 (2.10; 1.72-2.55; P <0.001) CV events

Reference:

  1. El-Taji O, Taktak S, Jones C, Brown M, Clarke N, Sachdeva A. Cardiovascular Events and Androgen Receptor Signaling Inhibitors in Advanced Prostate Cancer: A Systematic Review and Meta-Analysis. JAMA Oncol. Published online June 06, 2024. doi:10.1001/jamaoncol.2024.1549

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.