Round Up Email December 2025

while the exact prevalence of eosinophilic asthma is uncertain, it is estimated to represent about 90% of all severe asthma cases

blood eosinophilia is correlated with an increased risk of asthma exacerbation, so with increasing blood eosinophil counts, exacerbation becomes more severe

in children aged 5 to 16 years NICE suggest that a significant blood eosinophil count is if the eosinophil count is more than 0.5 x 10⁹ per litre (500 cells/μL)

delgocitinib is a novel topical steroidal pan‐Janus kinase (JAK) inhibitor impacting JAK enzymatic activity and targeting key mediators of chronic hand eczema

clinical trial evidence shows that delgocitinib is more effective at improving symptoms of chronic hand eczema than alitretinoin or 'vehicle cream' (a cream that does not contain an active ingredient)

delgocitinib has not been directly compared in a clinical trial with phototherapy, but an indirect comparison suggests that delgocitinib is more effective

a recent BMJ umbrella review of systematic reviews found that existing evidence absolutely refutes any link between maternal paracetamol use during pregnancy with autism or ADHD in offspring

a Swedish study (185,909 children exposed to paracetamol during pregnancy from database of 2 480 797 births), using sibling control analysis, found no evidence of association with autism, ADHD & intellectual disability

a meta-analysis (n=73,881 mother-child pairs) showed that children prenatally exposed to paracetamol were 19% more likely to subsequently have autism spectrum conditions and 21% more likely to have ADHD symptoms vs. non-exposed children

pulsatile tinnitus is a possible symptom of intracranial hypertension

in the UK, the number of reports of idiopathic intracranial hypertension occurring in patients treated with mesalazine is very low

background incidence of idiopathic intracranial hypertension has been reported as between 70 and 100 per 100,000 population per year across Scotland, England and Wales

with respect to bathing if eczema, European guidelines recommend only a short duration (5 min) with the use of bath oils in the last 2 min of bathing

most international guidelines recommend bathing daily for about 5–10 min with warm water and using emollients immediately after bathing

a recently published study by Bradshaw et al, found that daily bathing was the optimum frequency for improvement in eczema symptoms

losartan is the most studied angiotensin receptor blocker in the role as a migraine prophylaxis

the candesartan dose used in trials for adults in the prevention of migraine, was 16mg per day

data from 2 randomised controlled trials suggest that around 40% of patients taking the trial dose of candesartan will have a clinically significant reduction in their number of headache days per month