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AIRE trial

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

2006 patients with acute myocardial infarction, complicated at any time by left ventricular failure, were randomised to:

  • ramipril, an ACE-inhibitor, 5 mg twice daily
  • placebo

Randomisation took place 3-10 days post-MI (mean 5 days).

Treatment with ramipril resulted in:

  • an absolute reduction in mortality of 6%
  • an odds reduction for death of 26%
  • the prevention of 45 premature deaths per 1000 patient years


  • Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. (1993). Lancet, 342, 821-8.

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