Class I comprises the sodium channel blockers.
Class I drugs are subdivided into three groups according to the effect each has on the duration of the action potential:
The upstroke of the action potential in myocytes is mediated by sodium - thus alteration of sodium flux has the most potent effect on ventricular arrhythmias.
Note that other texts may subdivide the class I antiarrhythmics on the basis of their kinetics - Ia being the fastest acting, etc.
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