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Comparative effects of low-dose rosuvastatin, placebo and dietary supplements on lipids

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Comparative Effects of Low-Dose Rosuvastatin, Placebo and Dietary Supplements on Lipids and Inflammatory Biomarkers

  • a study compared the efficacy of a low-dose statin with placebo and six common supplements in impacting lipid and inflammatory biomarkers

  • was a single-center, prospective, randomized, single-blind clinical trial among adults with no history of atherosclerotic cardiovascular disease (ASCVD), an LDL-C of 70-189 mg/dL and an increased 10-year risk of ASCVD

  • participants were randomized to 5 mg daily of rosuvastatin, placebo, fish oil, cinnamon, garlic, turmeric, plant sterols or red yeast rice

  • primary endpoint was the percent change in LDL-C from baseline for rosuvastatin 5 mg daily compared with placebo and each supplement after 28 days. The primary endpoint was evaluated in a hierarchical fashion with rosuvastatin first compared with placebo, then each supplement in a prespecified order using ANCOVA

  • study results
    • 190 participants completed the study
    • percent LDL-C reduction with rosuvastatin was greater than all supplements and placebo (p <0.001)
    • difference in LDL-C reduction with rosuvastatin compared with placebo was -35.2% (95% confidence interval, -41.3 to -29.1, p <0.001)
    • none of the dietary supplements demonstrated a significant decrease in LDL-C compared with placebo
    • adverse event rates were similar across study groups

  • study authors concluded:
    • among individuals with increased 10-year risk for ASCVD, rosuvastatin 5 mg daily lowered LDL-C significantly more than placebo, fish oil, cinnamon, garlic, turmeric, plant sterols, and red yeast rice

Reference:

  • Laffin LJ et al. Comparative Effects of Low-Dose Rosuvastatin, Placebo and Dietary Supplements on Lipids and Inflammatory Biomarkers. J Am Cardiol Nov 06, 2022

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