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Doubling statin dose - approximate increase in cholesterol lowering if double dose of statins

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

  • if the dose of a statin is doubled then there is an approximate 6% increase in LDL lowering efficacy by doubling the dose - the so-called 6 percent rule

     
    • for example
      • rosuvastatin statin 5mg produces an approximate LDL reduction of 40% - if the dose of rosuvastin is doubled to 10mg then there is an approximate 46% LDL reduction expected with this dose of rosuvastatin
      • pravastatin 20mg produces an approximate LDL reduction of 24% - if the dose of pravastatin is doubled to 40mg then there is an approximate 30% LDL reduction expected with this dose of pravastatin

    • the "6 percent rule" holds approximately for all statins (1,2)

Reference:

  • J Am Coll Cardiol. 2003;42(2):398-399
  • Personal opinion - Jim McMorran (29/3/13). GP with Specialist Interest in Diabetes and Lipids (Coventry PCT) and Editor GPnotebook.

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