Interleukin-1
Interleukin-1, IL-1, is a glycoprotein cytokine first described in the 1940s. There are two subtypes: IL-1 alpha is intracellular and associated with antigen presentation; IL-1 beta is the main extracellular form.
IL-1 is intimately involved in immune responses and chronic inflammation. Excessive, persistent IL-1 release has been implicated in the pathogenesis of rheumatoid arthritis, cachexia and atherosclerosis.
It is produced in the following cells:
- mononuclear phagocytes: the major source
- antigen-presenting dendritic cells
- neutrophils
- B-lymphocytes
- keratinocytes
- endothelial cells
- renal cells
Therapeutic administration of interleukin-1 e.g. as a cytotoxic agent, has largely been limited by side effects such as pyrexia.
Reference
- Dinarello CA. Overview of the IL-1 family in innate inflammation and acquired immunity. Immunol Rev. 2018 Jan;281(1):8-27
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