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Radioiodine labelled fibrinogen uptake

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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The uptake of radioiodine (I,125) labelled fibrinogen may be used to detect thrombus throughout the calf and in the lower three quarters of the thigh.

It is a highly sensitive technique. Only 50% of DVT's detected on labelled fibrinogen scanning are identified clinically and studies using this technique reveal post operative DVT in up to 30% of patients over 40 years old.

Despite these results, however, the technique is falling out of favour, as:

  • it cannot detect thrombus which has formed before the labelled fibrinogen is given
  • it is unreliable in the pelvic and hip region, since the bladder is in close proximity and may contain excreted radioiodine
  • it is of little use following knee or hip surgery since labelled fibrinogen accumulates at the site of the operation
  • it is contraindicated during pregnancy
  • lower limb incisions may give false positive results
  • there is a risk of hepatitis

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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