This site is intended for healthcare professionals

CPD
CPD
Pro
Pro
Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Go to /pro/cpd-dashboard page

This page is worth 0.05 CPD credits. CPD dashboard

Go to /account/subscription-details page

This page is worth 0.05 CPD credits. Upgrade to Pro

Interactions

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Amiodarone is metabolised by hepatic cytochrome P450 3A4(CYP 3A4) isoenzyme:

  • concomitant administration of CYP 3A4 inhibitors should either be avoided or used only with caution
  • CYP 3A4 inducers (e.g. carbamazepine, rifampicin) may lead to a reduction in amiodarone's plasma concentration and therefore reduce efficacy
  • amiodarone itself inhibits CYP 3A4 and therefore will increase plasma concentrations of drugs such as ciclosporin, phenytoin and verapamil

Other important interactions with amiodarone include:

  • potentiation of the effects of warfarin (inhibits metabolism via CYP 3A4)

  • reduces excretion of digoxin (leads to increased plasma concentration)

  • contra-indicated with other drugs that prolong the QT interval (e.g. disopyramide, quinidine, procainamide); only specialists should co-prescribe and monitor such drug therapy

Reference:

  1. Drug and Therapeutics Bulletin (2003), 41 (2), 9-12.

Related pages

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.