Sulphasalazine is potentially toxic and so must be carefully monitored (1,2).
FBC, LFTs
Watch for trends as well as absolute levels of:
Any patient receiving sulphasalazine should be advised about the need to have a full blood count immediately if they develop unexplained purpura, bleeding, bruising, sore throat, fever or excessive tiredness (1).
FBC, LFTs Every 1-2 weeks for 2 months; then 3-monthly for a year; then 6-monthly
Ideally results should be recorded in a patient-held booklet.
Reference:
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