urticaria and angio-oedema can lead to significant stress and the converse is also recognized namely that psychological stress can trigger or aggravate urticaria
possible mechanism for the latter is through stress-induced release of corticotrophin-releasing hormone (CRH)
known to be expressed locally in the skin
in chronic urticaria there is up-regulation of the CRH-R1 receptor that mediates CRH-dependent cutaneous mast cell degranulation
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