Block and replace regime (in thyrotoxicosis)
An alternative to treatment with antithyroid drugs alone, block and replace therapy comprises of
- constant dose if thionamide (e.g. - carbimazole 40 mg daily) to block thyroid hormone production
- add levothyroxine to maintaineuthyroidiims (e.g. - 100 µg daily for women, 125 µg daily for men)
This regime may be continued for 18 months, and propylthiouracil may be used if carbimazole is not well tolerated.
Disadvantages of this regime are that the large number of tablets may result in poor compliance and it is argued that the physician is unable to gauge the likelihood of relapse. Advantages of this regimen however are that under or over treatment is avoided whilst better use is made of carbimazole's immunosuppressive action.
Reference:
Related pages
Create an account to add page annotations
Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.