Carbimazole and pancreatitis

Carbimazole: risk of acute pancreatitis

• if acute pancreatitis occurs during treatment with carbimazole, immediately and permanently stop treatment. Re-exposure to carbimazole may result in life-threatening acute pancreatitis with a decreased time to onset

Advice for healthcare professionals:

• cases of acute pancreatitis have been reported very infrequently during treatment with carbimazole
• if acute pancreatitis occurs, stop carbimazole treatment immediately
• do not use carbimazole in patients with a history of acute pancreatitis in association with previous treatment
• re-exposure may result in life-threatening acute pancreatitis with a decreased time to onset
• report suspected adverse drug reactions to the Yellow Card Scheme immediately

Reference:

• MRHA (February 2019). Drug Safety Update 12(7):1-8.