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Clinical features

Authoring team

The clinical features vary according to aetiology.

In previously untreated patients:

  • intensification of pre-existing symptoms, especially nausea, vomiting, epigastric pain
  • possibly, fever
  • lethargy
  • hypotension
  • hypovolaemic vascular shock

In patients previously treated with glucocorticoids, hypovolaemic shock is a late finding since mineralocorticoid secretion is usually preserved.

Reference

  1. Husebye ES, Pearce SH, Krone NP, et al. Adrenal insufficiency. Lancet. 2021 Feb 13;397(10274):613-29.
  2. Bancos I, Hahner S, Tomlinson J, Arlt W. Diagnosis and management of adrenal insufficiency. Lancet Diabetes Endocrinol. 2015 Mar;3(3):216-26

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