Clinical features
The clinical features vary according to aetiology.
In previously untreated patients:
- intensification of pre-existing symptoms, especially nausea, vomiting, epigastric pain
- possibly, fever
- lethargy
- hypotension
- hypovolaemic vascular shock
In patients previously treated with glucocorticoids, hypovolaemic shock is a late finding since mineralocorticoid secretion is usually preserved.
Reference
- Husebye ES, Pearce SH, Krone NP, et al. Adrenal insufficiency. Lancet. 2021 Feb 13;397(10274):613-29.
- Bancos I, Hahner S, Tomlinson J, Arlt W. Diagnosis and management of adrenal insufficiency. Lancet Diabetes Endocrinol. 2015 Mar;3(3):216-26
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