usually needs to be injected once or twice a day e.g. isophane insulin (Neutral Protamine Hagedorn [NPH]), such as Human Insulatard® Humulin I®, (also porcine and bovine equivalents)
isophane insulin - forms insoluble crystals and injected as a suspension when administered via subcutaneous injection
long-acting insulin analogues
can last for a longer period than intermediate acting insulins e.g. glargine Lantus® (has a peakless action profile; injected daily), detemir Levemir® (maximal effects after 6–8 hours; injected daily or twice a day)
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