Total glycated haemoglobin (GHb)
Total Glycated hemoglobin
- defined as hemoglobin with glucose bound to any of these potential sites
- HbA1c is a subset of glycated hemoglobins. It is defined as hemoglobin with glucose bound at the beginning (N-terminal) of the ß-chain
- total glycated hemoglobin (total GHb) will include HbA1c plus all the other hemoglobins (including haemoglobin variants) that have glucose bound to lysine side chains and/or to the N-terminal of the alpha-chain
- HbA1c is the major subfraction of the glycated normal hemoglobin (HbA1)
- HbA1c is the major subfraction of the glycated normal hemoglobin (HbA1)
- generally about half of the glucose is bound to the HbA1c position with the other half bound at 3 or 4 other sites (lysines)
- HbA1c is a subset of glycated hemoglobins. It is defined as hemoglobin with glucose bound at the beginning (N-terminal) of the ß-chain
Reference interval:
- Diabetes > =9.0%
- Risk of diabetes 7.3 to 9%
- Healthy adult: 3.9% to 7.3%
Note that reference ranges may vary between laboratories and based on the assays used.
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